DNA serves as a foundational component across multiple therapeutic modalities, from templates for mRNA and viral vectors to raw materials for cell and gene therapies. Designing DNA with downstream processing in mind is critical to ensure scalability, product quality, and regulatory compliance. This workshop will explore key design and process considerations that influence DNA manufacturability, purity, and functional performance. Participants will examine how DNA sequence design, synthesis methods, and process architecture affect subsequent purification and formulation steps across different therapeutic platforms.

Join this workshop to:

• Explore design factors (vector architecture, sequence composition, size, and topology) that DNA processability and downstream behavior
• Select the right capture method: comparing resin based, HIC and affinity techniques across modalities
• Evaluate the interplay between DNA quality attributes (supercoiling, residuals, impurities) and product performance in various modalities
• Discuss emerging technologies for scalable DNA manufacturing, from enzymatic synthesis to continuous downstream platforms