From Template to Transcript: Impact of DNA Product Quality on mRNA Therapeutic Outcomes

• Designing DNA vectors to influence double-stranded RNA formation and improve downstream process performance
• Engineering a plasmid that impacts polyA tail length to maximize product quality
• Understanding the importance of pDNA as a starting material on mRNA product quality to inform plasmid design

Speakers:

François de Mets

Principal Scientist

GlaxoSmithKline