Controlling Variability in Downstream Processing to Produce Quality Plasmid DNA at Industrial Scale

• Understanding how downstream processes impact DNA isoforms (supercoiled vs nicked/linear)
• Identifying the main causes of DNA damage during DSP: hold-up time and temperature during resuspension
• Exploring how DNA quality impacts stability

Speakers:

Narendran Sekar

Senior Scientist & Head - Process Development

GreenLight BioSciences