Controlling Fermentation Environments to Reduce Variability for Reproducible, High-Quality Plasmid Supply
- Unpacking key challenges in upstream fermentation and parameters to monitor during fermentation
- Reducing fermentation stresses to maintain plasmid robustness, sequence integrity and minimize batch-to-batch variability
- Balancing growth and yield to maximize efficiency while preserving critical elements like polyA tails for mRNA and ITRs for viral vectors
- Evaluating media formulation, feeding strategies and culture conditions for optimal plasmid recovery